When to Choose Lubricated Condoms or Not Condoms protect against unplanned pregnancy and most sexually transmitted infections, including HIV, gonorrhoea, chlamydia, and syphilis. Use only water or silicone based lubricant with a condom during vaginal and particularly anal sex Oil based lube can cause some condom materials to break. Instead, use water based or silicone lube with condoms. Remember: Condoms do more than just help prevent pregnancy. Using condoms with new partners Do spermicide condoms work? Pros and cons Trojan ENZ Classic Reservoir End Latex Condoms with Spermicidal Lubricant, 12 ct Fry's Food Stores